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Clinical trials show that a percentage of patients discontinue semaglutide due to gastrointestinal adverse effects

Key Takeaway: While both medications target the GLP-1 pathway to reduce hunger, tirzepatide adds a second pathway (GIP) to further support metabolic health

doi: 10.1016/j.omtm.2022.09.014 23 BankheadPLoughreyMBFernandezJADombrowskiYMcArtDGDunnePDet al

Patients appreciate when we anticipate these issues rather than reacting only after they become distressing

DSIP does not appear to share these mechanisms Z-drugs (e.g., zolpidem) associated with REM suppression and rebound insomnia

Instead, focus on a balanced diet with plenty of fruits, vegetables, lean proteins, and whole grains to help support your treatment plan