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According to the classic two-hits model, the increased insulin resistance, secondary to metabolic syndrome, determines an excessive lipid accumulation in healthy hepatocytes (first hit), mainly through an increased mobilization of free fatty acids from visceral adipose tissue to the liver

A large-cohort study also revealed that lack of maternal folic acid supplementation at peri-conception resulted in increased risk for a DS birth due to errors occurred at maternal meiosis II in the aging oocyte, and it was shown that the methylation status of chromosome 21 peri-centromeric regions could favor recombination errors during meiosis leading to its malsegregation

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First, phase II clinical trials evaluating MOTS-c in type 2 diabetes and sarcopenia are in development, and their results will provide the first randomized controlled evidence in humans to define therapeutic doses with statistical rigor

After thorough safety and efficacy evaluations, along with in vivo and in vitro model studies, the most promising antifungal compounds in preclinical and clinical development include novel triazoles, glucan synthase inhibitors, and small-molecule polypeptides