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Before prescribing, clinicians should confirm appropriate indicationseither inadequately controlled type 2 diabetes or obesity with BMI 30 kg/m (or 27 kg/m with weight-related comorbidities such as hypertension or dyslipidemia)

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Over-replacement is associated with symptoms of hyperthyroidism, including palpitations, weight loss, heat intolerance, and osteoporosis from long-term high doses

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