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CD138+ plasma cell differentiation was also increased by PPP activity but was inhibited, along with proliferation, during DHEA or 6-AN treatment 136

Am J Physiol 268:G673G684 Kimura H, Miura S, Shigematsu T, Ohkubo N, Tsuzuki Y, Kurose I, Higuchi H, Akiba Y et al (1997) Increased nitric oxide production and inducible nitric oxide synthase activity in colonic mucosa of patients with active ulcerative colitis and Crohns disease

CLINICAL TRIAL EVIDENCE FOR GLP-1 RAs IN MASH Table 2 provides a summary of phase 2 and phase 3 studies examining GLP-1 RAs and dual or triple agonists (aiming glucagon, GIP, and GLP-1 receptors) in individuals with MASLD/MASH, where hepatic biopsies were used to evaluate liver outcomes [3,5,10,11,15,22-25,44-52]

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