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Nanoparticle-based delivery systems have emerged as a promising approach for brain-targeted therapy, provided they exhibit favorable physicochemical and safety profiles (Masserini 2013)

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The DAMPs released by different PCD modes (such as HMGB1, oxidized lipids, mtDNA, etc.) amplify tissue damage signals into persistent inflammatory stimuli through PRRs/NLRs (141, 142)