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Left panel : Low-dose IV ACh primarily activates endothelial M3 muscarinic receptors, stimulating nitric oxide (NO) release and vascular smooth muscle relaxation, resulting in arterial vasodilation and reduced blood pressure

In parallel, retrograde signaling originating from chloroplasts under high light conditions, together with abscisic acid (ABA)-dependent pathways, exemplifies how ROS link environmental cues to nuclear gene regulation (Mittler et al

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We demonstrate applicability beyond 5FU treatment in CRC to any TS-targeted therapeutics in other disease subtypes

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