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Further research has shown that selenium is involved in supporting key brain signalling pathways such as GABA and dopamine signalling within the central nervous system, which is of particular importance in conditions such as Alzheimer's and Parkinson's disease

The mechanisms include blood pressure reduction, improvement in lipid profiles, anti-inflammatory effects on the arterial wall, and possible direct cardioprotective effects through GLP-1R expressed on cardiomyocytes

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Joseph Rizzo, senior author of the July 2024 study that found an association between semaglutide and NAION, called the condition, in effect, a stroke of the optic nerve. Rizzo is the director of neuro-ophthalmology at Mass Eye and Ear in Boston

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The cold sensitivity on GLP-1 compounds is another commonly reported experience that resolves as the body adapts to new weight and metabolic patterns