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Side Effects and the Copper Uglies Explained GHK-Cu has a strong safety profile in topical research, but a small subset of users experience a transient phase known as the copper uglies. A 2023 clinical safety review covering 12 studies and 512 participants reported that the most common side effects of topical GHK-Cu were transient and mild

Side effects may decrease (because the effective dose is lower), giving a false impression that tolerance has developed

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It makes B12 a less likely explanation, though a borderline number alongside ongoing symptoms is still worth a second look

They specifically looked at the hippocampus, the region of the brain that consolidates new memories and is associated with learning

However, when its weakened, your body can struggle to fight off even common infections