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Molecular and cellular actions of a structural domain of human growth hormone (AOD9401) on lipid metabolism in Zucker fatty rats Journal of Molecular Endocrinology, 2000 Dec, Volume 25 (Issue 3), Pages 287-98

The increased production of reactive oxygen species (ROS) and inflammation creates a detrimental feedback loop, as ROS have the ability to initiate pro-inflammatory pathways and stimulate the secretion of cytokines, thereby exacerbating tissue injury and inflammation associated with brain injury