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The peptides occupy the extracellular domain and the orthosteric pocket, whereas the small molecules wedge into the transmembrane region around Trp33
BPC-157 and TB-500 work through entirely separate mechanisms, so simultaneous injection is standard practice
Also, combined effects produce results exceeding personal ingredients
The pharmacokinetic difference is small enough that it wouldn't change efficacy or side-effect profile in a meaningful way
Commun Biol (2023) 6(1):327
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