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Vardjan, N

J Clin Invest 2003

Both IFN- and TNF- are key players in the induction of cell-mediated immunity and granuloma formation to effectively control an M

ROS and oxidatively modified macromolecules function as damage-associated molecular patterns (DAMPs), engaging pattern recognition receptors (PRRs) on microglia, including Toll-like receptors (TLRs) and NOD-like receptors (NLRs), to initiate inflammatory cascades ( Microglia, the resident immune cells of the CNS, are tightly regulated under physiological conditions to maintain neural homeostasis

Int J Mol Sci (2017) 18(11):2362

References Townsend DM, Tew KD, Tapiero H