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The dose escalation period represents the most challenging phase, and strategic timing of supportive peptides can ease this transition
Therefore, UA boosted the anti-tumor activity of sorafenib in tumor xenograft models
It does not carry the dramatic cautions of, say, high-dose vitamin C, which requires G6PD screening
Most tolerability information comes from rodent studies and a small number of uncontrolled human observations
That chain is too many steps removed from reality to hold up clinically
Carcinogen metabolism in human lung tissues and the effect of tobacco smoking: results from a casecontrol multicenter study on lung cancer patients
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