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Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunity

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Interestingly, we found that succinate accumulated only in Gclc- deficient B cells and not in Gclc- deficient effector T cells nor Tregs 43,44

These techniques offer the possibility of modulating network excitability, protein aggregation, and glial function without a pharmacological burden

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In addition, metabolites associated with amino acid metabolism and redox balance, such as lysine, arginine, and spermine, display multiple interactions with other metabolic nodes