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For weight management , NHS access to GLP-1 medications is limited to specialist weight management services

"Once-weekly semaglutide 24 mg versus once-daily liraglutide 30 mg for weight management (WEGO): a multicentre, double-blind, double-dummy, randomised controlled trial." New England Journal of Medicine, Accessed July 10, 2023, Eli Lilly and Company

Early studies suggest improvements in: HbA1c Fasting glucose Triglycerides Liver fat content Waist circumference Long-term metabolic outcomes are still under investigation

Some people achieve their goals at 4mg or 8mg without needing the highest dose

HSP72 protects against obesity-induced insulin resistance

Symptoms usually subside once the body stabilizes on a maintenance dose.