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Oxidation of reactive cysteines represents a multi-step process involving a deprotonated thiol and the reaction of active thiolate with H 2 O 2 37,38,39,40,41 (Supplementary methods)

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Studies on organ specificity

During the initial treatment period with methylcobalamin, pulmonary edema and congestive heart failure have reportedly occurred early in treatment with parenteral methylcobalamin