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Longo et al., 2025)

Prefer Different Administration Format The Problem: Mounjaro comes in pre-filled pen only Prefer vial and syringe (more control, less waste) Pen design difficult for some to use Environmental concerns about pen disposal The Solution: Some alternatives offer vials instead of pens, providing more flexibility

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Differential effects of once-weekly glucagon-like peptide-1 receptor agonist dulaglutide and metformin on pancreatic -cell and insulin sensitivity during a standardized test meal in patients with type 2 diabetes

Several others are in late-stage testing: Orforglipron (Eli Lilly): This one is a pill, not an injection

This is the milestone where clinical benefit becomes unambiguous