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Treatment with Semaglutide mitigated these abnormalities, restoring autophagic flux and lysosomal function, and consequently attenuating AGEs-BSA-induced calcification in MOVAS

First, the optimization of the Nrf2 pathway through targeted drug delivery, e.g., lipid nanoparticles (LPNs) loaded with sulforaphane or bardoxolone methyl could enhance endothelial uptake while avoiding systemic side effects (Zhang et al., 2024), and LNPs conjugated to VCAM-1 antibodies for inflamed vasculature targeting (Gu et al., 2025)

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Treatment with oral semaglutide resulted in a mean A1C reduction from baseline of -1.3% at week 52 for both estimand calculations

KLOW is one of two flagship CoreVionRX research blends the four-compound KLOW and the three-compound GLOW

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