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Comorbid conditions, such as diabetes and chronic kidney disease, amplify ketamines neurotoxicity by increasing oxidative stress and impairing drug metabolism
For patients with no neurological involvement Initial treatment : IM hydroxocobalamin 1 mg 3 times a week for 2 weeks
TNF induces matrix metalloproteinase-9 expression in monocytic cells through ACSL1/JNK/ERK/NF-kB signaling pathways
White et al, 2016)
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e.g., the lowest FIO 2 needed to maintain an arterial O 2 saturation 90%
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