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Every minute your vial spends at a temperature above 8 degrees Celsius, degradation is happening faster than it needs to

However, there is no evidence of withdrawal symptoms in the traditional sense when discontinuing GLP-1 receptor agonists

Am J Physiol Endocrinol Metab 301:E797E806 Donelan MJ, Morfini G, Julyan R, Sommers S, Hays L, Kajo H, Braud I, Easom RA, Molkentin JD, Brady ST, Rhodes CJ (2002) Ca 2+ -dependent dephosphorylation of kinesin heavy chain on -granules in pancreatic -cells

Schmidt AC, Leroux JC Drug discovery today 2020

Itd be interesting if Makary pushed back on this peptide deregulatory effort, but that seems relatively unlikely

This is a good starting point