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Grunvald E, Shah R, Hernaez R, Chandar AK, Pickett-Blakely O et al (2022) AGA clinical practice guideline on Pharmacological interventions for adults with obesity

[4] These hybrids achieved higher GH release in some assays, demonstrating that ipamorelin's structure could serve as a scaffold for next-generation secretagogue design

This difference in mechanism explains why GLP-1 therapy typically produces significantly larger weight reductions

doi: 10.1016/j.isci.2024.109784 39 YingXRongjiongZKahaerMChunhuiJWulasihanM

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