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13a, Supplementary Table 9), suggesting that the distinct rotamer orientation of H296 ECL2 in Cagri-bound CTR (to accommodate the Glu linker) and/or the observed more open ECL3 conformation induced by the lipidated peptide may facilitate or stabilize an active CTR conformation (Supplementary Fig

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These data are in line with the expectations generated by previous trials with GLP-1 agonists, such as LEADER and REWIND, and suggest that tirzepatide may exert a cardioprotective effect independent of glycemic control, possibly through anti-inflammatory mechanisms, improved endothelial function and lipid control

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