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Serious but rare adverse effects associated with injectable GLP-1 receptor agonists include acute pancreatitis, gallbladder disease (cholecystitis and cholelithiasis), and potential thyroid effects
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Reduce the risk of cardiovascular events in patients with diabetes and heart disease
Animal research suggests several converging mechanisms: modulation of the nitric oxide pathway , upregulation of VEGF driving angiogenesis, interaction with the growth-hormone-receptor pathway , and modulation of inflammatory cytokines including TNF- and IL-6
It works by mimicking the incretin hormone GLP-1, which slows gastric emptying, reduces appetite, and influences brain regions that control food intake
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