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By maintaining higher metabolic rate during calorie restriction, GIP agonism may prevent the plateaus that limit weight loss with other interventions

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Another concern some people experience with rapid weight loss is changes in skin elasticity or mild sagging skin

The SUSTAIN (Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes) trial series began enrolling patients in 2012, ultimately encompassing multiple phase 3 trials with thousands of participants worldwide