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The pathways with the strongest human-relevant evidence are the peripheral anti-inflammatory effects (reduction in systemic hs-CRP and cytokines) and the systemic metabolic improvements (glycemic control, weight reduction), both of which are well-documented in clinical data

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PLoS ONE 9(8):e103929 Burstein R, Jakubowski M, Garcia-Nicas E et al (2010) Thalamic sensitization transforms localized pain into widespread allodynia

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GH-Axis Activation and Hepatic Fat Metabolism GH has well-documented lipolytic properties

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