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NRF2 then dimerizes with members of the sMaf proteins through its bZIP domains and binds to the ARE sequences, which are regulatory enhancers, within gene promoters [156, 161]
More recently, we also evidenced that starvation induced p38 MAPK activation, which by reprogramming glucose metabolism by the pentose phosphate pathway sustains NADPH production
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the copper-bound form (GHK-Cu) is the active molecule responsible for its tissue remodeling properties
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