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But a quieter, more dangerous conversation is emerging in the background: Why are so many patients developing peripheral neuropathy after starting these drugs

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Starting at 250-300mcg regardless of body weight, then adjusting based on response, often works better than jumping to weight-based higher doses

However, comparisons between short and long term exposure of GLP-1R agonists in the presence of the GLP-1R antagonist Exendin-9, on neurite outgrowth, neuronal sensitivity and TRPV1 expression in thoracic and lumbosacral DRG are required, and will be the focus of future studies

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