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10.1161/STROKEAHA.109.549592 Stroke 41 SugawaraT.AyerR.JadhavV.ZhangJ

These parameters were applied consistently across all ligandprotein complexes, including designed peptides, the endogenous ligand, and the reference peptide, ensuring that the calculated binding enthalpies are directly comparable and physically meaningful [21, 71] within the implicit solvent framework