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4 Insulin is reserved for patients with more advanced diabetes, a condition that is itself a risk factor for cancer
Losing muscle accelerates your metabolic rate decline, makes future weight regain faster and harder to reverse, and affects your strength, your energy, and your functional capacity for the next 20 years
However, the translation of these findings to human obesity remains limited by important physiological differences between rodents and humans, including the lower abundance and activity of brown adipose tissue in adults and an overall reduced thermogenic capacity
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GIP is involved in glucose and lipid metabolism, GLP-1 regulates insulin secretion and appetite, and GCG plays a role in energy expenditure and substrate utilisation
doi: 10.1038/s41413-022-00237-6 25 ZajcACzarneckaARutkowskiP
