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Nat Commun 15 , 10623 (2024)

5 GLP-1RAS 5.1 Biological characteristics of GLP-1RAs and their cardiovascular action basis The GLP-1R is expressed in the human pancreas, intestines, and heart, with distribution across all four cardiac chambers and predominant localization in the sinoatrial node (110)

These medications work by mimicking a hormone in the body that helps control blood sugar levels, manage appetite, and reduce cravings

Global sensitivity analysis is then applied to examine the model behavior and identify the pathways with the greatest impact in control compared to RP conditions

They include the weekly injectable drugs Zepbound (FDA approved for weight loss and sleep apnea) and Mounjaro (FDA approved for improving blood sugar levels in people with Type 2 diabetes, but often prescribed off-label for weight loss)

Each area has advantages and considerations that inform how you build your rotation schedule