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Use is especially high among adults ages 50 to 64 and among individuals with diabetes, heart disease, or obesity
Constipation was less common than with some single-target GLP-1 compounds, possibly due to the glucagon component stimulating gut motility
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The technology rapidly progressed with several types of co-agonists forging ahead in clinical trials including GIP/GLP-1 receptor dual agonists with one of the most notable being tirzepatide [8,9]
Similar exposureresponse relationships were observed for efficacy (HbA1c and body weight) and tolerability (nausea and vomiting) of semaglutide, regardless of the route of administration [58]
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