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The combination of metformin and semaglutide represents a scientifically grounded approach to addressing both insulin resistance and appetite regulation
Many patients find that avoiding high-fat, spicy, and sugary foods during the first month reduces nausea episodes by 40-50%
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The mechanism of action involves several complementary pathways: Enhanced insulin secretion : GLP-1 agonists stimulate glucose-dependent insulin release from pancreatic beta cells, meaning insulin is only released when blood glucose levels are elevated, thereby reducing the risk of hypoglycaemia
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