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2301-C E3 UBIQUITIN LIGASE NEDD4 IS A KEY NEGATIVE REGULATOR FOR GSDMD-MEDIATED PYROPTOSIS IN NON-ALCOHOLIC STEATOSIS Rui Jin, Xiaoxiao Wang, Baiyi Liu, Zilong Wang, Yuyun Song, Xiaohe Li, Feng Liu and Huiying Rao, Peking University People's Hospital, Peking University Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Beijing International Cooperation Base for Science and Technology on NAFLD Diagnosis Background: Pyroptosis mediated by GSDMD is thought to be involved in NASH development, but the roles of GSDMD in the pathogenesis of NASH are not fully understood

Clinical efficacy, safety and tolerability of collagenase Clostridium histolyticum for the treatment of peyronie disease in 2 large double-blind, randomized, placebo-controlled phase 3 studies

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For researchers investigating chronic low-grade inflammation (often called inflammaging), it offers a well-characterized tool compound for studying simultaneous antioxidant and anti-inflammatory responses without the systemic suppression that comes from corticosteroids or broad NSAIDs

The Cardioprotective Mechanisms of Natural Products Regulating Nrf2-Associated Cellular Processes in Cardiovascular Diseases Apart from targeting the Nrf2/Keap1 interaction, some cardioprotective natural products were found to regulate Nrf2-associated cellular processes