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Several -hydroxy fatty acids are substrates for the synthesis of a specialized class of sphingolipids identified as the -hydroxyceramides and the -O-acylceramides

Additionally, the dense cartilage ECM and rapid synovial fluid turnover hinder exosome retention and uptake

PMID: 2

This can help soften expression lines like forehead wrinkles or crow's feet over time

Certain clinical scenarios might warrant a more gradual approach to discontinuation, even though not pharmacologically necessary

Attia is also the host of a weekly podcast, The Drive, in which he has very deep conversations with medical practitioners about the latest scientific research