when was semaglutide fda approved Approves Wegovy Weight-Loss Pill FDA Approves Semaglutide to Prevent

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2015 / updated page

Future Directions: Dual and Triple Agonists in NASH The evolution of incretin-based therapies for NASH now extends beyond single GLP-1 receptor agonists to multi-target approaches with enhanced metabolic effects

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Chronic hyperglycemia is responsible for many complications, including cardiovascular disease, nerve damage (neuropathy), kidney damage (nephropathy), eye disease, unintentional weight loss (due to metabolism of fat and muscle, as cells do not have access to glucose to metabolize), and diabetic ketoacidosis

Several studies demonstrated IL-6 to regulate glucose tolerance and insulin action (107, 108) and furthermore, IL-6 was shown to enhance insulin secretion by increasing GLP-1 production in L cells and alpha cells, leading to improved glucose tolerance (109)