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Side effects are common and can be significant, including muscle loss, nausea, and gastrointestinal issues
Although the hypotensive effect of GLP-1 RAs seems to be manifested by BW losing, other mechanisms not related to BW might be implied by the mediation meta-analysis, which suggests an existence of BW-independent hypotensive effect of GLP-1 RA, along with the clinical evidence of weak or no correlations, and difference in time course between BP lowering and BW reducing effects
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Study monitoring Independent oversight committees included the Data Monitoring Committee (DMC), the Trial Steering Committee (TSC) and the Trial Management Committee, and were held on a regular basis throughout the trial
Pull out the needle after injecting the right dosage
