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Mostly gastrointestinal nausea, vomiting, diarrhea, and constipation described as predominantly mild to moderate and dose-dependent, plus a modest heart-rate increase in the higher arms
This cascade crosstalks with the ErbB2, PI3K/Akt, and MAPK pathways, thereby circumventing trastuzumab-mediated HER2 inhibition and promoting drug resistance
The Source: Information for this article was taken from a Novo Nordisk news release published on Dec
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Dynamics within the CD95 deathinducing signaling complex decide life and death of cells
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