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A randomized, placebo-controlled, phase II study of obeticholic acid for primary sclerosing cholangitis
Chinese Journal of Chemical Engineering, 2019,34(06):1327-1338
The only therapeutic approach currently in clinical trials is AAV2-BDNF gene therapy, which requires neurosurgical implantation
we check thyroid levels before prescribing levothyroxine, testosterone and estrogen before starting hormone replacement, insulin secretion capacity before choosing between diabetes drug classes
They span molecular dynamics simulations, quantitative systems pharmacology (QSP), PK/PD modelling, organ-on-chip computational frameworks, and machine learning approaches
It keeps the sterility and efficacy of formulation intact
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