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281 By reducing macrophage-mediated inflammatory responses, GLP-1RAs have the potential to alleviate symptoms of OA, including pain and joint stiffness

Practical Application Omega-3 rich fish: Salmon, mackerel, sardines, anchovies Monounsaturated fats: Extra virgin olive oil, avocados, almonds Plant-based omega-3s: Flaxseeds, chia seeds, walnuts Medium-chain triglycerides: Coconut oil (moderate amounts) Include healthy fats in each meal (10-15 grams per meal) Pair fats with protein and fiber for sustained L-cell activation Avoid excessive saturated fat which may impair L-cell function Strategy 5: Meal Composition and Sequencing The Science: L-cells dont just respond to individual nutrientsthey respond to the pattern, sequence, and combination in which nutrients arrive

For example, the nonsteroidal anti-inflammatory drug fenoprofen exerts its anti-inflammatory action by inhibiting prostaglandin (PG) biosynthesis through COX blockade

While GLP-1 drugs can be effective, tolerance varies widely, and finding the right fit may require adjustments or alternative treatments

Tashiro H et al

Metabolic Benefits: By promoting weight loss, these medications may help reduce the risk of developing or worsening weight-related health problems, such as Type 2 diabetes, cardiovascular disease, sleep apnea, osteoarthritis and certain types of cancer