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In support of this, we prepared primary cultures of cerebellar granule cells from Bdnf-Luc mice using a 96-well culture plate, and found that membrane depolarization increased luciferase activity, which agreed with previous reports regarding the activity-dependent Bdnf expression in cultured cerebellar granule cells 32,33

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MOTS-c promotes NRF2 activation, upregulating genes for glutathione synthesis, superoxide dismutase, and catalase [3]

For most patients, yes