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Key limitations: Some compounds have direct human pharmacodynamic data

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Thus, as long as senescent cells are removed, this mechanism mainly promotes rejuvenation of tissues and tissue repair

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A retrospective cohort study in JACC (2004) found that after RALES publication, real-world spironolactone prescribing in heart failure was associated with a 6-fold increase in hyperkalemia-related hospitalizations when monitoring was not maintained