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Focus: Improving formulations, patient access, and expanding indications

4 Mechanisms of hepatoprotection by GLP-1RAs as immune-metabolic modulators 4.1 Immunomodulatory mechanism of hepatic injuries by GLP-1RAs GLP-1RAs reduce inflammation, downregulate pro-inflammatory cytokines, and influence immune cell differentiation via the GLP-1 receptor, which alters macrophage polarization and inhibits fibrosis ( 4.1.1 GLP1-RAs attenuate the inflammation in MASLD by downregulating multiple inflammatory factors In animal models, GLP-1RAs have shown promising results in decreasing the expression of various inflammatory markers, including TLR2 and C-X3-C chemokine receptor 1 (CX3CR1), as well as reducing the expression of genes related to liver fibrosis and fat accumulation

Weight Loss Efficacy Current data suggests the injectable form may produce slightly more weight loss for some patients

Safety concerns: Dosing errors can happen easily with self-adjustment, and long-term impacts of microdosing havent been studied

We would therefore recommend powered quantitative studies investigating changes in psychiatric symptoms pre- and post-treatment with GLP-1 receptor agonists

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