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Hayes JD, Pulford DJ

Not only is obesity connected to heart disease, diabetes, certain types of cancer, and other serious health conditions, but a 2024 analysis estimates that obesity accounts for nearly $173 billion in annual healthcare system costs and over $347 billion in direct employer and employee costs, underscoring the massive economic burden tied to obesity in the U.S

However, the initial site of metformins action remains the gut, leading us to believe that the gastrointestinal tract is the primary target of metformins action

It also improves blood sugar control, although it is not FDA-approved to treat type 2 diabetes, though a lower-dose version of liraglutide (Victoza) is

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