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Bredel M, Scholtens DM, Yadav AK, Alvarez AA, Renfrow JJ, Chandler JP, et al

The findings confirmed significant lean mass reductions in larger trials, though they noted that body composition improvements were generally favorable when looking at fat-to-lean ratios

Will there ever be a direct head-to-head trial

Some individuals prefer avoiding injections and may feel more comfortable with a pill

[2] During a monotherapy clinical trial of topiramate in the treatment of epilepsy in adults, chest pain (unspecified) was reported in 1% of patients receiving 50 mg/day and 2% of patients receiving 400 mg/day