The REDEFINE 3 cardiovascular outcomes trial which will take several years to complete is not a prerequisite for initial market authorisation for obesity treatment, but its results will likely be important for subsequent label expansion and for establishing the cardiovascular benefit profile that has proven so valuable for tirzepatide and semaglutide
Chen C, Zheng X, Wang C, Zhou H, Zhang Y, Ye T, Yang Y
Beneficial effect of a novel pentadecapeptide BPC 157 on gastric lesions induced by restraint stress, ethanol, indomethacin, and capsaicin neurotoxicity
Moreover, evidence on the long-term efficacy and safety of prolonged use, as well as combination therapy with other drugs, remains insufficient
While mild to moderate fatigue is common with GLP-1s, it should not be debilitating
Vitamin E Dry, damaged strands prone to split ends and breakage indicate Vitamin E deficiency