Coenzyme Q10 supplementation for prophylaxis in adult patients with migraine-a meta-analysis
Yet the heaviness, bloating, constant fatigue, strange hunger pains, and burning keeps coming back
Hachicha M, Naccache PH, McColl SR: Inflammatory microcrystals differentially regulate the secretion of macrophage inflammatory protein 1 and interleukin 8 by human neutrophils: a possible mechanism of neutrophil recruitment to sites of inflammation in synovitis
Molecules 25:4410
Common side effects include nausea, diarrhea, vomiting, constipation, stomach discomfort, rash or pain around the injection site, fatigue, burping, hair loss, and gastroesophageal reflux disease
Alternative medication classes should be considered if GLP-1 therapy proves intolerable: SGLT2 inhibitors (such as dapagliflozin, empagliflozin) for type 2 diabetes, which work via a completely different mechanism and rarely cause gastrointestinal side effects DPP-4 inhibitors (such as sitagliptin, linagliptin), which enhance endogenous GLP-1 activity more gently Metformin remains first-line for type 2 diabetes, though it can also cause gastrointestinal side effects Orlistat for weight management, though this also has gastrointestinal side effects of a different nature For weight management specifically, NICE recommends a comprehensive approach including dietary modification, increased physical activity, and behavioural interventions, with or without pharmacotherapy