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Methylcobalamin and methionine are particularly sensitive to oxidative degradation, and the lipotropic amino acids (choline, inositol, methionine) begin breaking down into inactive metabolites within days at ambient temperature
doi: 10.1158/1535-7163.MCT-06-0494 59 PopSEnciuAMTarcomnicuIGilleETanaseC
USA17SEM02889 October 2017 SOURCE Novo Nordisk
Importantly, the effects mediated by SANA occur through an increase in creatine-related energy expenditure, reminiscent of creatine-dependent thermogenesis, or futile creatine cycle 30,31 , a heat-production pathway that can maintain body temperature in the complete absence of UCP1 expression 32
Therefore, TRZ has a good therapeutic window with minimal toxicity (Min and Bain 2021)
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