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all remain extrapolated from preclinical data and observational experience with no controlled human trial validation

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Theoretical Important limits No controlled interaction studies exist

Vitamin B12 Essentials 2.1 Biochemical Roles and Neurological Importance Vitamin B12 (cobalamin) is indispensable for two biochemical pathways: Methionine Synthase : Converts homocysteine to methionine, fueling methylation reactions vital for DNA synthesis, neurotransmitter production (serotonin, dopamine), and myelin maintenance

The authors also thank members of the Touchstone Diabetes Center for their helpful critical reading of this manuscript