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Start your intake How Phentermine and Ozempic Work Differently Phentermine is a sympathomimetic amine that increases norepinephrine release in the brain, elevating heart rate, blood pressure, and central nervous system activity to reduce appetite

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More than 4 million items of tirzepatide and semaglutide were dispensed on the NHS in England in 2025/2026 1 , while around 2.5 million people each month accessed GLP-1s privately at the end of 2025, according to James Kingsland, chair of the Digital Clinical Excellence (DiCE) network of primary care digital health providers

Step 4: Stool softeners and lubricants Docusate sodium (Colace) 100-200 mg twice daily Mineral oil 15-30 mL daily (oral or rectal) Stool softeners are the least effective option for GLP-1 constipation because the primary problem is motility, not stool hardness

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