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Exendin-4 preserves blood-brain barrier integrity via glucagon-like peptide 1 receptor/activated protein kinase-dependent nuclear factor-kappa B/matrix metalloproteinase-9 inhibition after subarachnoid hemorrhage in rat

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This difference was likely attributable to the insufficient inhibition of excessive GJ proteins in hepsin / mice in response to the lower 2APB dose of 1 mg/kg, lending further support to the hypothesis that hepsin may help reduce APAP toxicity by regulating the expression of hepatic GJ proteins

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