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Biological actions of GLP-1, source: reference [1] Evolution of GLP1 GLP-1RAs Currently, there are nine GLP-1RAs approved for marketing worldwide (Table 1), mainly for the treatment of diabetes and obesity, of which tirzepatide is a novel dual GLP-1RA/GIPR agonist

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Weight loss with Tirzepatide continued gradually through the full 72-week treatment period, with some participants still losing weight at the end of the trial

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